Description

AMINOGARD GRANULES

AminoGard Granules powder, 5 g (sachet)

OVERVIEW

Aminogard granules, when combined with concentrated calorie sources (like hypertonic dextrose or fat emulsion), electrolytes, vitamins, and minerals, offer a biologically utilizable source material for protein synthesis. Aminogard granules will assist in keeping the body in shape for increased fitness and overall health as well as the muscles ready for peak performance. The body will receive what it needs from an ongoing, sufficient supply of amino acids, and this will improve the ratio of muscle to fat. Any anticatabolic or anabolic strategy must include higher doses of essential micronutrients (thiamine, riboflavin, pyridoxine, folic acid), as these nutrients are depleted following trauma or during the healing process.

Compound description

orange-yellow to pale yellow-coloured, flavoured, free-flowing granular powder.

Composition

Each 5 g of aminogard granules contains:

L-Isoleucine USP                                            100mg

L-Leucine USP                                                 125mg

L-Valine USP                                                     75mg

L-Lysine Hydrochloride USP                           150mg

L-Methionine USP                                             25mg

L-Threonine USP                                               25mg

L-Phenylalanine USP                                        50mg

L-Tryptophan USP                                             5mg

L-Proline USP                                                     25mg

L-Glutamine USP                                                150mg

L-Arginine USP                                                    100mg

Thiamine Hydrochloride BP                              5mg

Riboflavin Sodium Phosphate BP

Equivalent to Riboflavin                                      5mg

Pyridoxine Hydrochloride BP                             1.5mg

Folic Acid BP                                                        0.5mg

Cyanocobalamin BP                                            5mcg

(as gelatin coated)

Appropriate overages of vitamins are added to compensate for the loss during storage.

Indication

Aminogard Granules are used to treat, manage, prevent, and alleviate the following conditions, diseases, and signs:

1. Component of parenteral nutrition
2. Leg pain due to blocked arteries
3. Negative nitrogen balance
4. High blood pressure
5. Malnutrition
6. Heart attack
7. Chest pain

Pharmacokinetics

 Unlike fats and carbohydrates, amino acids require the removal of the amine group. Removal of the amine group occurs through a 2-step process: transamination reaction and oxidative deamination. All excess amino acids are deaminated. This results in the production of ammonia, which is toxic and is eliminated via the urea cycle. The urea cycle occurs in the liver, resulting in the formation of urea, which is eliminated by excretion as urine.

The liver is the major site of nitrogen metabolism in the body. The carbon skeletons are generally conserved as carbohydrates via gluconeogenesis or as fatty acids via fatty acid synthesis pathways.

In this respect, amino acids fall into three categories: glucogenic, ketogenic, or glucogenic and ketogenic. Glucogenic amino acids are those that give rise to a net production of pyruvate or TCA cycle intermediates, such as a-Ketoglutarate or Oxaloacetate, all of which are precursors to glucose via gluconeogenesis.

Dosage

One sachet of aminogard may be taken twice daily. Not recommended for children under the age of two.

Dissolve the contents of the sachet in 200 ml of water or juice and consume immediately or directly with a glass of water.

Side-effects

The following is a list of possible side-effects that may occur from all constituting ingredients of Aminogard Granules. These side-effects are possible but do not always occur. Some of the side effects may be rare but serious. 

• Metabolic imbalances
• Hyperammonemia
• High nitrogen in the blood
• Stupor
• Coma
• Aluminum poisoning

Precautions

Before using Aminogard Granules, inform your pharmacist about your current list of medications, over-the-counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side effects of the drug. The dosage is based on your condition. Tell your pharmacist if your condition persists or worsens. Important counseling points are listed below.

• Asthma
• Ensure you are getting sufficient calories while on this medication
• Hepatic impairment
• Must be diluted before administration
• Needs to be diluted
• Pregnant, planning to become pregnant, or breastfeeding
• Renal impairment

STORAGE

Store below 30 degrees Celsius and away from direct sunlight.

Keep it out of the reach of children.