Description

LIQUID IRON SYRUP

LIQUID IRON SYRUP (100ML)

OVERVIEW

Liquid iron syrup is indicated in iron deficiency anemia caused by trauma, surgery, hookworm infestation, child delivery, menstruation, and dietary deficiency; in situations of increased iron demand such as in pregnancy and lactation; as well as in growing children and for the elderly with the problem of poor iron ingestion or absorption.

Liquid iron syrup is also indicated in convalescence from prolonged and debilitating illness with symptoms such as weakness, lack of concentration, lassitude, pallor, and tiredness; anemia due to febrile illnesses like malaria, typhoid, and influenza.

COMPOSITION

Each 5ml contains:

Ferric Ammonium Citrate U.S.P                200 mg

(equivalent to 40 mg of elemental iron)

Folic Acid B.P                                           200mcg

Vitamin B12 B.P                                        3 mcg

CLINICAL PHARMACOLOGY

Liquid Iron Syrup is rich in iron salt, Ferric Ammonium Citrate and contains Vitamin B12.

Ferric Ammonium Citrate is one of the best-tolerated iron supplements. It provides an optimum tolerance of the iron preparation, which is of utmost importance in maintaining long term patient compliance with any hematinic therapy. It rapidly supplements elemental iron so that iron deficiency is quickly controlled, thus leading to faster correction of anemia and replenishment of tissue iron stores.

Folic acid is a manmade (synthetic) form of folate. Your body can’t store large amounts of natural folate. But your body can easily absorb folic acid. As a result, it’s added to some of the foods you eat. Grains such as rice, bread, pasta, and some cereals are enriched (fortified) with folic acid. Folic acid is also available as a dietary supplement. Folate is a B vitamin found naturally in many of the foods you eat.

These foods include leafy greens, citrus fruits, nuts, beans, peas, seafood, eggs, dairy, meat, poultry, and grains. Your body needs folate to make new red blood cells and DNA, the genetic material in your cells. Folate is especially important for people who are pregnant. Folate helps in the growth and development of your unborn baby (fetus) and can help prevent birth defects.

Vitamin B-12 (cobalamin) plays an essential role in red blood cell formation, cell metabolism, nerve function, and the production of DNA, the molecules inside cells that carry genetic information.

Vitamin B12 is a water-soluble vitamin that is naturally present in some foods, added to others, and is available as a dietary supplement and a prescription medication. Because vitamin B12 contains the mineral cobalt, compounds with vitamin B12 activity are collectively called “cobalamins.” Methylcobalamin and 5-deoxyadenosylcobalamin are the metabolically active forms of vitamin B12. However, two other forms, hydroxycobalamin and cyanocobalamin, become biologically active after they are converted to methylcobalamin or 5-deoxyadenosylcobalamin.

Vitamin B12 is required for the development, myelination, and function of the central nervous system; healthy red blood cell formation; and DNA synthesis. Vitamin B12 functions as a cofactor for two enzymes, methionine synthase and L-methylmalonyl-CoA mutase.

Methionine synthase catalyzes the conversion of homocysteine to the essential amino acid methionine. Methionine is required for the formation of S-adenosylmethionine, a universal methyl donor for almost 100 different substrates, including DNA, RNA, proteins, and lipids . L-methylmalonyl-CoA mutase converts L-methylmalonyl-CoA to succinyl-CoA in the metabolism of propionate, a short-chain fatty acid.

Vitamin B12 is bound to protein in food and must be released before it is absorbed. The process starts in the mouth when food is mixed with saliva. The freed vitamin B12 then binds with haptocorrin, a cobalamin-binding protein in the saliva. More vitamin B12 is released from its food matrix by the activity of hydrochloric acid and gastric protease in the stomach, where it then binds to haptocorrin.

In the duodenum, digestive enzymes free vitamin B12 from haptocorrin, and this freed vitamin B12 combines with intrinsic factor, a transport and delivery binding protein secreted by the stomach’s parietal cells. The resulting complex is absorbed in the distal ileum by receptor-mediated endocytosis. If vitamin B12 is added to fortified foods and dietary supplements, it is already in free form and therefore does not require the separation step.

INDICATIONS

Liquid iron syrup can be used for the following;

• Iron deficiency anemia
• Treatment of megaloblastic anemias due to a deficiency of folic acid
• Treatment of anemias of nutritional origin, pregnancy, infancy, or childhood
• Vitamin b12 deficiency
• Pernicious anemia

DOSAGE

Children : 6-12 years 5ml two times daily.

Adults : 5ml – 10 ml two times daily

Pregnancy and stress : 5ml two times daily

SIDE EFFECTS

The side effects associated with liquid iron syrup includes;

• Gastrointestinal problems
• Stomach pain
• Black stools
• Allergic reactions
• Anorexia
• Nausea
• Abdominal distention
• Flatulence
• Bitter or bad taste
• Altered sleep patterns
• Difficulty in concentrating
• Irritability
• Overactivity
• Excitement
• Mental depression
• Confusion
• Impaired judgment
• Decreased vitamin b12 serum levels
• Seizures in epileptic patients receiving phenobarbital, primidone, or diphenylhydantoin
• Decreased diphenylhydantoin serum levels in folate-deficient patients
• Swelling
• Rapid weight gain
• Diarrhea
• Itching or mild rash

STORAGE

Store it in a cool,dry environment.

Keep away from light